COF-366

Angiogenesis
- Src
- FLT3
- VDA
- HIF
- FGFR
- Syk
- FAK
- BTK
Apoptosis
- Bcl-2
- TNF-alpha
- Mdm2
- Survivin
- p53
- Caspase
- IAP
- PERK
Autophagy
Cell Cycle
- Aurora Kinase
- ROCK
- PLK
- CDK
- Rho
- Wee1
- Chk
- APC
- c-Myc
Cytoskeletal Signaling
- HSP (e.g. HSP90)
- Microtubule Associated
- Kinesin
- PAK
DNA Damage
- PARP
- ATM/ATR
- DNA/RNA Synthesis
- Telomerase
- Topoisomerase
- PPAR
- DNA-PK
Endocrinology & Hormones
- Androgen Receptor
- Aromatase
- Estrogen/progestogen Receptor
- 5-alpha Reductase
- RAAS
- GPR
Epigenetics
- HDAC
- Sirtuin
- DNA Methyltransferase
- Epigenetic Reader Domain
- Histone Methyltransferase
- Histone demethylases
- Histone Acetyltransferase
GPCR & G Protein
- S1P Receptor
- MT Receptor
- CaSR
- LPA Receptor
- PAFR
- Endothelin Receptor
- Cannabinoid Receptor
- CGRP Receptor
- OX Receptor
- SGLT
- Adenosine Receptor
- cAMP
- Vasopressin Receptor
- CXCR
- Protease-Activated Receptor
- Prostaglandin Receptor
JAK/STAT
- JAK
- STAT
- Pim
MAPK
- MEK
- p38 MAPK
- Raf
- JNK
- ERK
Metabolism
- Factor Xa
- Phospholipase (e.g. PLA)
- P450 (e.g. CYP17)
- DHFR
- PDE
- Carbonic Anhydrase
- Hydroxylase
- Dehydrogenase
- Transferase
- MAO
- Aminopeptidase
- HMG-CoA Reductase
- Procollagen C Proteinase
- FAAH
- Phosphorylase
- CETP
- IDO
- Ferroptosis
Microbiology
- Integrase
- CCR
- Reverse Transcriptase
Neuronal Signaling
- GluR
- Opioid Receptor
- GABA Receptor
- Adrenergic Receptor
- 5-HT Receptor
- P2 Receptor
- COX
- Dopamine Receptor
- AMPA Receptor-kainate Receptor-NMDA Receptor
- AChR
- Histamine Receptor
- Beta Amyloid
NF-κB Signaling
- IκB/IKK
- NOD1
- NF-κB
PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- PDK-1
- PKA
- AMPK
- S6 Kinase
Proteases
- Proteasome
- DPP-4
- Cysteine Protease
- HCV Protease
- HIV Protease
- Gamma-secretase
- BACE
- MMP
- DUB
- Serine Protease
Protein Tyrosine Kinase
- VEGFR
- EGFR
- IGF-1R
- Bcr-Abl
- HER2
- PDGFR
- c-Kit
- c-Met
- ALK
- Tie-2
- Ephrin receptor
- Axl
- Trk receptor
- CSF-1R
Stem Cells & Wnt
- Hedgehog/Smoothened
- Wnt/beta-catenin
TGF-beta/Smad Signaling
- PKC
- TGF-beta/Smad
Transmembrane Transporters
- CFTR
- Sodium Channel
- Calcium Channel
- Proton Pump
- Potassium Channel
- ATPase
- P-gp
- CRM1
Ubiquitin
- E3 Ligase
- p97
- E1 Activating
- E2 conjugating
- Deubiquitinase
Others
- Substance P
- IL Receptor
- Lysyl Hydroxylase
- Thrombin
- Liver X Receptor
- gp120/CD4
- FXR
- TRPV
- Integrin
- Dynamin
- Other inhibitors

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